Overview

We have developed a number of in-house proprietary technologies and models to accelerate your preclinical drug development.
Our experts will design custom-made project plans and support you in conducting comprehensive data analysis.
Our results will help you choose or validate drug candidates, anticipate potential toxicity or consider drug repurposing in various fields: type2 diabetes, metabolic disorders, oxidative stress etc.

microscope

Our Value can be summarized in
the following main categories:

Scientific Expertise

Our internationally recognized experts have extensive in vitro and in vivo research experience, particularly in metabolic and cardiovascular diseases.

Customer Focus

We strive to conduct projects and deliver data that answer you need.

Quality

We conduct each program with the utmost attention to the highest level of quality and efficiency.

Dermocosmetic

01

In vitro Safety
& Efficacy Evaluation

We have developed an innovative amperometry-based method for the ultrasensitive detection Reactive Oxygen Species (NO and H2O2) in real time, which can be used to predict the antioxidant capacity of new skin treatment compounds.

Number of scientific studies have demonstrated the key role of NO and H2O2 in regulating the skin's balance. Released in small quantities by the skin barrier cells, these mediators are involved in processes essential to the maintenance of good skin health (cell renewal, respiration, scarring, permeability, melanogenesis, cell communication, etc.). On the other hand, when the skin is subjected to stress (oxidative agents, exacerbated inflammation, pollution, etc.), the exacerbated release of NO and H2O2 leads to alterations in vital biological processes, which damage the skin balance (lipid peroxidation, irreversible DNA damage, mitochondrial dysfunction, breakdown of the barrier function, etc.).

This method allows :

  • To validate the antioxidant activity of your compounds on skin models, either short or long-term: (NMEs, natural extracts, formulations, etc.)
  • To compare the antioxidant profile of your bioactive molecules to a reference compound
  • To use our proprietary skin models, adapt them or develop tailor-made models
dermocosmetic schema

Custom stress
test models

At Enterosys, we can use our testing models, adapt them or develop tailor-made skin stress models.

Atopic Dermatitis

Atopic
Dermatitis

Erythema

Erythema

Chemically-induced stress

Chemically-
induced stress

Bacterial-mediated skin infacetion

Bacterial-
mediated skin
infection

Emotionnal disorders

Emotionnal
disorders

Environnemental polluants

Environnemental
polluants

Nutraceutic

02

In vitro or in vivo Safety
& Efficacy evaluation

Neutraceuticals, a contraction of “nutrition” and ”pharmaceuticals”, are products that include dietary supplements and functional food. Our current lifestyle (more sedentary, increasing use of junk food or generally inappropriate nutrition) favors the emergence of many metabolic and cardiovascular diseases. Nutraceutical compounds are developed to prevent these diseases or improve our health and well-being.

Enterosys relies on a highly qualified team and technical platform to evaluate the efficacy and toxicity of your drug candidate in in vitro and / or in vivo models

  • Screening of potential compounds
  • Improved lead profiling and selection
  • Characterization or consolidation of the therapeutic effects
  • Characterization or consolidation the mechanism of action
  • Repositioning of your compound

Preclinical development

03

In vitro or in vivo Safety
& Efficacy evaluation

We have developed an innovative proprietary amperometry-based method for the ultrasensitive detection Reactive Oxygen Species (NO and H2O2) in real time, used to predict the tissue-specific toxicity or the antioxidant capacity of new compounds.

NO and H2O2 play a key role in regulating the body homeostasis. Released in small quantities by a lot of cells, these mediators are involved in processes essential to the maintenance of good health (cell renewal, respiration, scarring, permeability, cell communication, neurotransmission etc.). On the other hand, when a tissue is subjected to stress (oxidative agents, exacerbated inflammation etc.), the exacerbated release of NO and H2O2 leads to alterations in vital biological processes, which damage the tissue balance (lipid peroxidation, irreversible DNA damage, mitochondrial dysfunction, breakdown of the barrier function, etc.).

This method allows :

  • To identify which of your leads may have ROS toxicity in vitro (NMEs, generics, natural extracts, etc.)
  • To compare the antioxidant profile of your bioactive molecules to a reference compound or a competing compound
  • To conduct ex vivo or in vivo comparison of various drug candidates in different organs
  • To use our testing models, adapt them or develop tailor-made models
preclinical schema

Therapeutic areas

With our Accelerator Laboratory as your pharma service technology solution of choice, you can expand your search for biomarkers and accelerate your drug development timeline. We are helping researchers advance the science of precision health.

therapeutic areas

Animal health

04

Collaboration with
animal health companies

Enterosys can collaborate with animal health companies to conduct preclinical evaluation dedicated to animal health market such as dogs and cats drugs or functional food and nutraceuticals.

Enterosys relies on a highly qualified team and technical platform to evaluate the efficacy and toxicity of your drug candidate in vitro and / or in vivo models

  • Screening of potential compounds
  • Improved lead profiling and selection
  • Characterization or consolidation of the therapeutic effects
  • Characterization or consolidation the mechanism of action
  • Repositioning of your compound