Innovative preclinical investigations for dermatologic disorders & diseases

Enterosys is a CRO scientifically rooted in the gut and gut-skin axis

The cutaneous epidermis constitutes a protective interface of the body of approximately 25 m2 and represents one of the largest epithelial surfaces in interaction with microbes. The skin is considered the first line barrier against the external environment. The gastrointestinal tract is one of the largest interfaces (30 m2) between the host and its environment.

Both the gut and the skin have a significant impact on human health and interact extensively with the microbiota itself, which is essential for the balance and homeostasis of the immune system.

Disorders & diseases interacting with the gut and gut-skin axiS

ACNE VULGARIS

is a chronic inflammatory disease of the pilosebaceous unit. Gut microbial dysbiosis has also been suggested to contribute to the inflammatory response seen in acne.

AGING

causes the formation of reactive oxygen species in the skin, which subsequently damages, resulting in cell death. Changes to the gut microbiota provide a protective effect by modulating the immune response to oxidative stress.

ATOPIC DERMATITIS

is a chronic inflammatory skin disease, characterized by immune dysregulation, skin barrier dysfunction, and microbial dysbiosis in both the skin and gut.

EMOTIONAL DISORDERS, STRESS, DEPRESSION

The skin pathologies are thought to be related to mood and psychological disorders. The gut-brain-skin axis has been used to explain correlations among the gut microbiota, emotional states and systemic and skin inflammation.

PSORIASIS

is an immune-mediated inflammatory skin disease. Alterations in both the skin and gut microbiota have been reported in patients with psoriasis.

ROSACEA

is another inflammatory skin condition, which has been associated with alterations in the gut microbiome and increased prevalence of inflammatory bowel disease.

At the cutting edge of preclinical studies in dermatologic diseases

The gut-skin axis describes the relationship by which the gut can influence the health of the skin due to its immunological and metabolic properties. The gut and skin barriers surprisingly share many characteristics and functionalities. In direct contact with the external environment, both organs are essential for immune and neuroendocrine function. The gut-skin axis results from this similarity. Other similarities between the gut and skin are the high rate of cell turnover, which inhibits adhesion and infection by pathogens and makes both tissues highly responsive to stress and anxiety.

Figure from Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis-Probiotics as new tools for skin disorder management? Exp Dermatol. 2019 Nov;28(11):1210-1218. doi: 10.1111/exd.14016. Epub 2019 Aug 28. PMID: 31386766.

Discover our preclinical models

Enterosys offers you a complete and innovative offer of preclinical protocols based on in vitro and in vivo efficacy tests.

Discover our approach

Our experience in R&D allows us to meet your objectives and offer you support for the design and development of new models, guided by our innovation management approach.

Discover our preclinical models

Enterosys offers you a complete and innovative offer of preclinical protocols based on in vitro and in vivo efficacy tests.

Discover our approach

Our experience in R&D allows us to meet your objectives and offer you support for the design and development of new models, guided by our innovation management approach.

Gut & gut-organs communication: major role in many disorders and diseases

GASTROINTESTINAL DISEASES

NEURODEGENERATIVE DISEASES

METABOLIC
DISEASES

Question about the contribution of Gut and Gut-organs axis to your preclinical studies and innovation portfolio ?

Our team of experts will be happy to answer all your questions and discuss with you to guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.