Innovative preclinical models in Gut and Gut-Brain Axis

a CRO offering validated, complete and innovative offer of in vitro and in vivo preclinical efficacy tests.

Scientifically rooted in the gut, our experts offer a holistic approach focused on digestive physiology and communication between the gut and peripheral organs to enhance your assets. Explore our wide range of in vitro and in vivo preclinical and translational tests.

THE GUT ORGANS APPROACH IS A CENTRAL PERSPECTIVE FOR THE PRECLINICAL STUDIES

GUT MICROBIOTA

GUT
LIVER

GUT
ADIPOSE

GUT
BRAIN

GUT
CARDIOVASC

GUT
SKIN

IN VITRO MODELS

2D intestinal epithelial cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation
Coculture intestinal epithelial & immune cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation
3D epithelial tissues
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation

INDICATIONS / PATHOLOGIES

  • Chronic constipation
  • Crohn’s disease
  • Diarrhea
  • Enteric neuropathies
  • Irritable bowel syndrome
  • Irritable bowel diseases

IN VIVO MODELS

Diet induced “leaky gut” phenotype
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
DSS induced colitis model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
Constipation model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
Diarrhea model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption

INDICATIONS / PATHOLOGIES

  • Chronic constipation
  • Crohn’s disease
  • Diarrhea
  • Enteric neuropathies
  • Irritable bowel syndrome
  • Irritable bowel diseases

INVITRO MODELS

2D hepatocytes
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Enzyme activity
  • Lipids metabolism & accumulation
  • Glucose metabolism
  • Detoxification

INDICATIONS / PATHOLOGIES

  • Hepatic steatosis
  • Hypercholesterolemia
  • Metabolic syndrome
  • NAFLD / NASH
  • Obesity
  • Overweight
  • Type 2 diabetes

INVIVO MODELS

High Fat Diet induced steatosis
  • Antioxidant capacity
  • NAFLD scoring
  • Immunomodulation
  • Enzyme activity
  • Lipids metabolism & accumulation
  • Detoxification

INDICATIONS / PATHOLOGIES

  • Hepatic steatosis
  • Hypercholesterolemia
  • Metabolic syndrome
  • NAFLD / NASH
  • Obesity
  • Overweight
  • Type 2 diabetes

INVITRO MODELS

2D adipocytes in collaboration with Diva Expertise
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Lipids metabolism & accumulation
  • Cell differentiation
DivaGuT model in collaboration with Diva Expertise
  • Intestinal absorption
  • Antioxidant capacity
  • Immunomodulation
  • Lipids metabolism & accumulation
  • Cell differentiation

INDICATIONS / PATHOLOGIES

  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabete

INVIVO MODELS

High Fat Diet induced obesity model
  • Body weight management
  • Glucose metabolism
  • Insulin resistance
  • Lipid metabolism
  • Antioxidant capacity
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
  • Antibacterial activity

INDICATIONS / PATHOLOGIES

  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabete

INVITRO MODELS

3D Minibrain (in progress)
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Neurite outgrowth

INDICATIONS / PATHOLOGIES

  • Alzheimer’s disease
  • Depression
  • Epilepsy
  • Multiple sclerosis
  • Parkinson’s disease
  • Psychological stress

INVIVO MODELS

High Fat Diet induced obesity mode
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
Neurogenerative model (in progress)
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Blood brain barrier permeability
  • Cognitive functions
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
Depression model (in progress)
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Blood brain barrier permeability
  • Cognitive functions
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption

INDICATIONS / PATHOLOGIES

  • Alzheimer’s disease
  • Depression
  • Epilepsy
  • Multiple sclerosis
  • Parkinson’s disease
  • Psychological stress

INVITRO MODELS

2D endothelial cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Vascular permeability

INDICATIONS / PATHOLOGIES

  • Atherosclerosis
  • Cardiovascular disorders
  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabetes

INVIVO MODELS

Isolated aorta
  • Antioxidant capacity
  • Vascular permeability

INDICATIONS / PATHOLOGIES

  • Atherosclerosis
  • Cardiovascular disorders
  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabetes

INVITRO MODELS

In vitro gut-skin model
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
2D keratinocytes with SkinMecachipTM from Cell&Soft
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation

INDICATIONS / PATHOLOGIES

  • Acne vulgaris
  • Atopic dermatitis
  • Depression
  • Emotional disorders
  • Psoriasis
  • Rosacea
  • Stress

Custom model for your preclinical studies

By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor made efficiency testing model

Custom model for your preclinical studies

By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor made efficiency testing model.

Question about the contribution of Gut and Gut-organs axis to your preclinical studies and innovation portfolio ?

Our team of experts will be happy to answer all your questions and discuss with you to guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.