A CRO with innovative preclinical models specialized in the gut and gut-brain axis

Our CRO offers validated and innovative complete preclinical efficacy tests in vitro and in vivo.

Scientifically rooted in the gut, our experts offer a holistic approach focused on digestive physiology and the modes of communication between the gut and peripheral organs to enhance your assets. Explore our wide range of in vitro and in vivo preclinical and translational tests.

Explore the gut organ approach for your preclinical studies

Click on the microbiota axis
Click on the liver axis
Click on the adipose axis
Click on the brain axis
Click on the cardiovasc axis
Click on the skin axis

GUT MICROBIOTA

GUT
LIVER

GUT
ADIPOSE

GUT
BRAIN

GUT
CARDIOVASC

GUT
SKIN

Click on the organ axis to find the preclinical models you need

GUT MICROBIOTA

GUT LIVER

GUT ADIPOSE

GUT BRAIN

GUT CARDIOVASC

GUT SKIN

Click on the organ axis to find preclinical models you need

IN VITRO GUT MICROBIOTA MODELS

2D intestinal epithelial cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation
Coculture intestinal epithelial & immune cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation
3D epithelial tissues
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
  • Absorption
  • Cell renewal & differentiation

IN VIVO GUT MICROBIOTA MODELS

Diet induced “leaky gut” phenotype
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
DSS induced colitis model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
Constipation model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption
Diarrhea model
  • Antioxidant capacity
  • Motility
  • Immunomodulation
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Absorption

INDICATIONS / PATHOLOGIES

  • Chronic constipation
  • Crohn’s disease
  • Diarrhea
  • Enteric neuropathies
  • Irritable bowel syndrome
  • Irritable bowel diseases

IN VITRO GUT LIVER MODELS

2D hepatocytes
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Enzyme activity
  • Lipids metabolism & accumulation
  • Glucose metabolism
  • Detoxification

IN VIVO GUT LIVER MODELS

High Fat Diet induced steatosis
  • Antioxidant capacity
  • NAFLD scoring
  • Immunomodulation
  • Enzyme activity
  • Lipids metabolism & accumulation
  • Detoxification

INDICATIONS / PATHOLOGIES

  • Hepatic steatosis
  • Hypercholesterolemia
  • Metabolic syndrome
  • NAFLD / NASH
  • Obesity
  • Overweight
  • Type 2 diabetes

IN VITRO GUT ADIPOSE MODELS

2D adipocytes in collaboration with Diva Expertise
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Lipids metabolism & accumulation
  • Cell differentiation
DivaGuT model in collaboration with Diva Expertise
  • Intestinal absorption
  • Antioxidant capacity
  • Immunomodulation
  • Lipids metabolism & accumulation
  • Cell differentiation

IN VIVO GUT ADIPOSE MODELS

High Fat Diet induced obesity model
  • Body weight management
  • Glucose metabolism
  • Insulin resistance
  • Lipid metabolism
  • Antioxidant capacity
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
  • Antibacterial activity

INDICATIONS / PATHOLOGIES

  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabete

IN VITRO GUT BRAIN MODELS

3D Minibrain (in progress)
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Neurite outgrowth

IN VIVO GUT BRAIN
MODELS

High Fat Diet induced obesity mode
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
Neurogenerative model (in progress)
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Blood brain barrier permeability
  • Cognitive functions
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption
Depression model (in progress)
  • Antioxidant capacity
  • Neurotransmission & central nervous system activity
  • Blood brain barrier permeability
  • Cognitive functions
  • Immunomodulation
  • Gut motility
  • Neurotransmission & enteric nervous system activity
  • Permeability & gut barrier function
  • Intestinal absorption

INDICATIONS / PATHOLOGIES

  • Alzheimer’s disease
  • Depression
  • Epilepsy
  • Multiple sclerosis
  • Parkinson’s disease
  • Psychological stress

IN VITRO GUT CARDIOVASC MODELS

2D endothelial cells
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Vascular permeability

IN VIVO GUT CARDIOVASC MODELS

Isolated aorta
  • Antioxidant capacity
  • Vascular permeability

INDICATIONS / PATHOLOGIES

  • Atherosclerosis
  • Cardiovascular disorders
  • Metabolic syndrome
  • Obesity
  • Overweight
  • Type 2 diabetes

IN VITRO GUT SKIN MODELS

In vitro gut-skin model
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation
  • Permeability & gut barrier function
2D keratinocytes with SkinMecachipTM from Cell&Soft
  • Viability & cytotoxicity
  • Antioxidant capacity
  • Immunomodulation

INDICATIONS / PATHOLOGIES

  • Acne vulgaris
  • Atopic dermatitis
  • Depression
  • Emotional disorders
  • Psoriasis
  • Rosacea
  • Stress

Custom model for your preclinical studies on gut and gut-organs axis

By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor made efficiency testing model

Custom model for your preclinical studies on the gut and gut-organ axis

By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor-made models for efficiency testing

Do you have a question about the contribution of gut models to your preclinical studies and innovation portfolio ?

Our team of experts will be delighted to answer all of your questions. We guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.