Innovative preclinical studies for neurodegenerative disorders & diseases

Enterosys is a CRO for preclinical studies scientifically rooted in the gut and gut-brain axi

While the idea that the brain can alter gut function has been documented and accepted, the evidence for intestinal signals that affect mood, behavior, cognitive function, metabolism… is less known.

The mutual impact of the gastrointestinal tract on brain function is summarized in the concept of the “gut-brain axis”. Numerous studies of this complex system have highlighted the multiplicity and varied nature of the different components of the axis. Experimental studies conducted in recent years have shown that neural circuits have a central but not unique role in the connections between the gut and the brain. Hormonal and immunological pathways, as well as the gut microbiota, integrate information, at the base of a complex network, whose dysfunction can have pathophysiological consequences, influencing not only gastrointestinal efficiency but also modulating central functions.

Neurologic disorders & diseases interacting with the gut and gut-brain axis

AGING

As we age, both the immune system and the gut microbiome undergo significant changes in composition and function that correlate with increased susceptibility to diseases.

ALZHEIMER’S DISEASE

leads to dementia. Emerging evidence is suggesting a relationship between gut microbiota, brain health and the risk to develop this disease.

AUTISM

spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition.

DEPRESSION

or Major depressive disorder (MDD) is a common mental illness. Evidence suggests that the gut microbiota and bidirectional communication axis between the gastrointestinal tract and the brain play an essential role in regulating brain functions and the pathogenesis of neuropsychiatric diseases.

EPILEPSY

Recently, evidence has emerged that a dysbiosis in the gut may be associated with certain forms of epilepsy. The relationship between the gut microbiota and epilepsy, summarize the possible pathogenic mechanisms of epilepsy from the perspective of the microbiota gut–brain axis.

MULTIPLE SCLEROSIS (MS)

is an inflammatory demyelinating disease of the central nervous system (CNS), the etiology of which is still unclear, albeit believed to result from an autoimmune attack on CNS components.

PARKINSON’S DISEASE (PD)

Increasing evidence suggests that PD starts in the gut, with retrograde transmission of misfolded alpha-synuclein spreading from the enteric nervous system (ENS) to higher brain centers along vagal afferents.

PSYCHOLOGICAL STRESS

alters gut-brain axis activity, potentially causing intestinal barrier dysfunction that induce, in turn, cognitive and mood impairments through exacerbated inflammation.

ALZHEIMER’S DISEASE

leads to dementia. Emerging evidence is suggesting a relationship between gut microbiota, brain health and the risk to develop this disease.

PARKINSON’S DISEASE (PD)

Increasing evidence suggests that PD starts in the gut, with retrograde transmission of misfolded alpha-synuclein spreading from the enteric nervous system (ENS) to higher brain centers along vagal afferents.

AUTISM

spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition.

EPILEPSY

Recently, evidence has emerged that a dysbiosis in the gut may be associated with certain forms of epilepsy. The relationship between the gut microbiota and epilepsy, summarize the possible pathogenic mechanisms of epilepsy from the perspective of the microbiota gut–brain axis.

AGING

As we age, both the immune system and the gut microbiome undergo significant changes in composition and function that correlate with increased susceptibility to diseases.

PSYCHOLOGICAL STRESS

alters gut-brain axis activity, potentially causing intestinal barrier dysfunction that induce, in turn, cognitive and mood impairments through exacerbated inflammation.

DEPRESSION

or Major depressive disorder (MDD) is a common mental illness. Evidence suggests that the gut microbiota and bidirectional communication axis between the gastrointestinal tract and the brain play an essential role in regulating brain functions and the pathogenesis of neuropsychiatric diseases.

At the cutting edge of preclinical studies in neurologic diseases

Impact of the gut microbiota on the gut-brain axis in health and disease. A stable gut microbiota is essential for normal gut physiology and contributes to appropriate signaling along the gut-brain axis and, thereby, to the healthy status of the individual.

Figure from Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012 Oct;13(10):701-12. doi: 10.1038/nrn3346. Epub 2012 Sep 12. PMID: 22968153.

Discover our preclinical models

Enterosys offers you a complete and innovative offer of preclinical protocols based on in vitro and in vivo efficacy tests.

Discover our approach

Our experience in R&D allows us to meet your objectives and offer you support for the design and development of new models, guided by our innovation management approach.

Discover our preclinical models

Enterosys offers you a complete and innovative offer of preclinical protocols based on in vitro and in vivo efficacy tests.

Discover our approach

Our experience in R&D allows us to meet your objectives and offer you support for the design and development of new models, guided by our innovation management approach.

Gut & gut-organs communication: major role in many disorders and diseases

GASTROINTESTINAL DISEASES

METABOLIC
DISEASES

DERMATOLOGICAL DISEASES

Question about the contribution of Gut and Gut-organs axis to your preclinical studies and innovation portfolio ?

Our team of experts will be happy to answer all your questions and discuss with you to guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.