We have developed an innovative amperometry-based method for the ultrasensitive detection Reactive Oxygen Species (NO and H2O2) in real time, which can be used to predict the antioxidant capacity of new skin treatment compounds.
Number of scientific studies have demonstrated the key role of NO and H2O2 in regulating the skin's balance. Released in small quantities by the skin barrier cells, these mediators are involved in processes essential to the maintenance of good skin health (cell renewal, respiration, scarring, permeability, melanogenesis, cell communication, etc.). On the other hand, when the skin is subjected to stress (oxidative agents, exacerbated inflammation, pollution, etc.), the exacerbated release of NO and H2O2 leads to alterations in vital biological processes, which damage the skin balance (lipid peroxidation, irreversible DNA damage, mitochondrial dysfunction, breakdown of the barrier function, etc.).