Did you know that the enteric nervous system, often referred to as our “second brain,” is composed of over 200 million neurons lining the digestive tract? It plays a critical role in maintaining digestive health and mediating the connection between the gut and the...
Did you know that trillions of microorganisms are working behind the scenes in your body to keep you healthy? Often called our “hidden organ,” the gut microbiota is an extraordinary ecosystem that influences much more than just digestion. How does this invisible...
Unlock the mystery of your digestive system! In this edition, we explore the vital roles of digestion and nutrient absorption, essential for maintaining health. Digestion is the process by which foods are broken down into smaller molecules, or nutrients, making them...
Have you ever wondered how your body turns the food you eat into the energy you need? The secret lies within the fascinating world of gut physiology. Your digestive tract is not just a simple tube for digestion—it’s a complex system designed to absorb essential...
The team event on January 11th and 12th, 2024, aimed to strengthen bonds, celebrate successes, and plan for the future. Highlights included reflecting on the previous year, presenting the 2023 report, and collectively implementing a Corporate Social Responsibility (CSR) approach. The team discussed and devised concrete initiatives to integrate sustainable practices, demonstrating their shared commitment to positive contributions to society and the environment.
In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.
In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.
The discovery of intestinal actors, such as enterosynes, able to modulate the ENS-induced duodenal contraction is an innovative approach. Among all the intestinal factors, the understanding of the role of gut microbes in controlling glycaemia remains a major target. For instance, we researched and demonstrated how the modulation of gut microbiota by prebiotics could permit the identification of novel enterosynes.
Targeting the enteric nervous system that controls gut motility is now considered as an innovative therapeutic way in T2D to limit intestinal glucose absorption and restore the gut‐brain axis to improve insulin sensitivity. So far, little is known about the role of glucose on duodenal contraction in fasted and fed states in normal and diabetic conditions.
Currently, the gut is considered a primary site for the development of pathologies that modify brain functions such as neurodegenerative (Parkinson’s, Alzheimer’s, etc.) and metabolic (type 2 diabetes, obesity, etc.) disorders. Deciphering the mode of interaction between microbiota and the brain is a real original option to prevent (and maybe treat in the future) the establishment of gut-brain disfunctions and associated pathologies.
