Enterosys participates in the opening meeting of the LEARN project

Non-alcoholic liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome (which includes abdominal obesity, hyperglycemia, dyslipidemia and hypertension), and the leading cause of liver disease. NAFLD, like the metabolic syndrome, is a strong predictor of the development of type 2 diabetes. NAFLD includes a spectrum of liver diseases such as steatosis, or fatty liver disease, characterized by an accumulation of lipids in the liver. Steatosis is a benign pathology but predisposes to severe forms such as inflammatory steatosis (steatohepatitis or NASH) that can lead to the deleterious stages of cirrhosis and liver cancer. NAFLD affects a significant proportion of the world’s population and is recognized as a major public health issue. All metabolic pathologies constitute important risk factors for cardiovascular morbidity and mortality through the occurrence of myocardial infarction and stroke.

The diagnosis of inflammatory forms of NAFLD (NASH) requires liver biopsies, invasive approaches associated with risks of bleeding. Moreover, the factors and mechanisms involved in the transition from one stage of the disease to another are not clearly identified. Various clinical trials of therapeutic molecules are underway but there are no drugs available for the treatment of NAFLD. Lifestyle interventions are the best treatment for NAFLD, but these behavioral changes are difficult to achieve and maintain over time.

Therefore, relevant preclinical models are needed to elucidate the factors and mechanisms involved in NAFLD and to identify predictive biomarkers for this disease. Epidemiological studies demonstrate a link between metabolic liver disease and a diet high in fat and sugar. The nutritional composition of carbohydrate and/or lipid diets influences the occurrence of metabolic pathologies. Different diets leading to the development of NASH (high fat diet, western diet) by mimicking this type of diet are available in animal experiments. Recent studies show that the quality of dietary proteins can also influence the development of NASH, with whey proteins playing a protective role against this pathology.

Non-alcoholic liver diseases have an impact on metabolic and endocrine disturbances and on blood coagulation. This project associates three teams with complementary expertise in these fields and a company from the Occitanie region and Enterosys, a young company that wishes to develop its expertise in this field.




Enterosys welcomes its new assistant engineer

Manon Carratala Lasserre joined the Enterosys team in November 2022 and is in charge of service delivery. She obtained a Master’s degree in Immunology and infectious diseases at the Paul Sabatier University in Toulouse. During her internships, she first worked on...

Enterosys participates in Biofit 2022 in Strasbourg

With the highest attending rate of academics, TTOs and research institutions, BioFIT is the place where academia-industry collaborations get started. BioFIT has taken on a whole new dimension becoming the meeting point in Europe for tech transfer and for sourcing...

Enterosys will attend NutrEvent 2022 in Nantes

NutrEvent is the event dedicated to innovation in Food, Feed, Nutrition and Health. This year, NutrEvent is back for its 8th edition in a hybrid format. This hybrid event will be held both in-person and online. Enterosys will be present with a validated, complete and...

Enterosys welcomes its new business developer

This month, Pauline Caseilles joined the Enterosys team as a Scientific Business Developer. Her mission: to publicize Enterosys' service offerings. Pauline obtained a Master’s degree in Health Biology and a Specialized Mastere in Marketing and Sales also in the field...

Antioxidant and anti-inflammatory properties of maternal milk

The high hydrostatic pressure processing of donor milk may better protect preterm infants from gut and liver pathologies compared to Holder pasteurization, which is currently used in most human milk banks Preterm infants are highly susceptible to oxidative stress due...