In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.

Pharmaceuticals
Enteric neurons and glycemia control
In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.
The enteric nervous system is our second brain
The enteric nervous system (ENS), referred to as the “second brain,” is an extensive network of different cell types located along the digestive tract.
Targeting our second brain to fight diabetes
The enteric nervous system (ENS) plays a key role in controlling the gut-brain axis under normal and pathological conditions, such as type 2 diabetes. The discovery of intestinal actors, such as enterosynes, able to modulate the ENS-induced duodenal contraction is considered a pioneering approach.
Highlighting the potential neurologic side effects of Beta-Blockers
In addition to their classical mode of action in the brain, circulating factors may modulate the release of reactive oxygen/nitrogen species (ROS/RNS) from endothelial cells that compose the blood-brain-barrier without entering the brain. Due to their high capacity to diffuse across membranes, ROS/RNS can reach neurons and modify their activity. This study investigates other mechanisms of actions in which beta-blockers may display a central effect without crossing the blood brain barrier.
Treating metabolic disorders by targeting the enteric nervous system: “Enterosynes” as therapeutic gut factors
The gut-brain axis is of crucial importance for controlling glucose homeostasis. Alteration of this axis promotes the type 2 diabetes phenotype. Recently, a new concept has emerged to demonstrate the crucial role of the enteric nervous system in the control of glycaemia via the hypothalamus.
Research
Categorie
Archives
Enteric neurons for functional applications in health care
Pharmaceuticals Studying the role of the Enteric Nervous System (ENS) in the development of gut-brain pathologies (e.g., Alzheimer’s, Parkinson’s, diabetes, aging, stress, visceral pain) is an ever-expanding research topic. Researchers are starting to propose numerous...
Enteric neurons and glycemia control
The gut-brain axis:You have a message from your gut In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain....
The enteric nervous system is our second brain
The enteric nervous system (ENS), referred to as the “second brain,” is an extensive network of different cell types located along the digestive tract. It consists in enteric neurons, enteric glial cells and interstitial cells of Cajal. This network of cells is...
Enterosys participates in Biofit 2022 in Strasbourg
With the highest attending rate of academics, TTOs and research institutions, BioFIT is the place where academia-industry collaborations get started. BioFIT has taken on a whole new dimension becoming the meeting point in Europe for tech transfer and for sourcing...
Enterosys will attend NutrEvent 2022 in Nantes
NutrEvent is the event dedicated to innovation in Food, Feed, Nutrition and Health. This year, NutrEvent is back for its 8th edition in a hybrid format. This hybrid event will be held both in-person and online. Enterosys will be present with a validated, complete and...